Tablet Presentation
Each Uncoated Tablet Contains:
Cyproheptadine Hydrochloride IP
eq. to Cyproheptadine HCl anhydrous 4 mg
Cyproheptadine is histamine blocker, it also blocks serotonin
It produces antiemetic effect by blocking the central muscarinic receptors
Indications
-
Allergic rhinitis
- Allergic conjunctivitis
- Migraine
Mechanism of action
It competitively inhibits the binding of the free histamine to its receptor and prevents its negative symptom, cyproheptadine also inhibits the serotonin in smooth muscles of the small intestine thus stimulates appetite
Pharmacokinetics
Absorption:
It is absorbed by the oral route of administration
Protein binding:
It is 99.9% bound to plasma proteins
Metabolism:
It is metabolized in the liver
Excretion:
It is excreted via urine
Side Effects
- Drowsiness
- Dizziness
- Insomnia
- Blurring of vision
- Loss of coordination
Contraindication
- Contraindicated in closed angle glaucoma
- Contraindicated in high blood pressure
Pregnancy:
Used only if benefits outweighs the risk
Storage
Store it at room temperature